Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

@article{Marn1996ApoptosisSB,
  title={Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.},
  author={M J del Cerro Mar{\'i}n and Antonio Fernandez and Roger J. Bick and Shawn M. Brisbay and L. M. Buja and Mark B. Snuggs and David James McConkey and Andrew von Eschenbach and Michael J Keating and T. J. McDonnell},
  journal={Oncogene},
  year={1996},
  volume={12 11},
  pages={2259-66}
}
Bcl-2 expression is associated with the progression of prostate cancer from androgen-dependence to androgen-independence. Bcl-2 is an integral membrane protein which localizes to mitochondria, endoplasmic reticulum, and the nuclear envelope. Using spectrofluorometry and laser confocal microscopy, the ability of bcl-2 to modulate intracellular Ca2+ was examined in the Dunning G prostate carcinoma cell line following apoptosis induction by adriamycin. Adriamycin and thapsigargin, an endoplasmic… CONTINUE READING
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