Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death.

  title={Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death.},
  author={Yan Cheng and Feng Qiu and Jian Huang and Shin-ichi Tashiro and Satoshi Onodera and Takashi Ikejima},
  journal={Archives of biochemistry and biophysics},
  volume={475 2},
Calpain, calcium-dependent cysteine protease, is reported here to impose the crucial influence on oridonin-induced L929 cell apoptosis and autophagy. We found that inhibition of calpain increased oridonin-induced Bax activation, cytochrome c release and PARP cleavage, indicating that calpain plays an anti-apoptotic role in oridonin-induced L929 cell apoptosis. To explore this potential anti-apoptotic mechanism, we inhibited calpain and proteasome activity in oridonin-induced L929 cell apoptosis… CONTINUE READING


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