Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.

@article{Kataoka2011ApoptosisSK,
  title={Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.},
  author={Keiichiro Kataoka and Yoshiko Tokutomi and Eiichiro Yamamoto and Taishi Nakamura and Masaya Fukuda and Yi-fei Dong and Hidenori Ichijo and Hisao Ogawa and Shokei Kim-Mitsuyama},
  journal={Journal of hypertension},
  year={2011},
  volume={29 1},
  pages={76-84}
}
OBJECTIVES High-salt diet is closely associated with the increase in cardiovascular events. However, the mechanism of high-salt-induced cardiovascular injury is unknown. The present study was undertaken to test our hypothesis that apoptosis signal-regulating kinase (ASK) 1 may be involved in salt-induced cardiovascular injury. METHODS Wild-type and ASK1-/- mice were fed a low-salt or a high-salt diet for 10 weeks and the effects of high-salt diet on food intake, urinary volume and electrolyte… CONTINUE READING

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