Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators

  title={Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators},
  author={Yuhui Hu and Hans Lehrach and Michal Janitz},
  booktitle={Molecular Biology Reports},
The functional analysis of chromosome 21 (Chr21) proteins is of great medical relevance. This refers, in particular, to the trisomy of human Chr21, which results in Down’s syndrome, a complex developmental and neurodegenerative disease. In a previous study we analyzed 89 human Chr21 genes for the subcellular localization of their encoded proteins using a transfected-cell array technique. In the present study, the results of the follow-up investigation are presented in which 52 human Chr21 genes… CONTINUE READING


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Publications referenced by this paper.
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