Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.

@article{Dong2003ApoptosisresistanceOH,
  title={Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.},
  author={Zheng Dong and Jin Zhao Wang and Fushin Yu and Manjeri A. Venkatachalam},
  journal={The American journal of pathology},
  year={2003},
  volume={163 2},
  pages={663-71}
}
Hypoxia is an important pathogenic factor in ischemic disease and tumorigenesis. Under hypoxia, some cells are irreversibly damaged, whereas others adapt to the stress and may become more resistant to injury. The mechanism underlying such adaptive responses is unclear. Our recent study showed hypoxic induction of inhibitor of apoptosis protein-2 (IAP-2). Here we have investigated the critical steps in the apoptotic cascade that are affected by hypoxia and have identified a role for IAP-2 in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…