Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.

@article{Brambilla1996ApoptosisrelatedFP,
  title={Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.},
  author={E. Papasso Brambilla and Adrien Negoescu and Sylvie Gazz{\'e}ri and Sylvie Lantu{\'e}joul and Diana Dal Moro and C. Brambilla and J. L. Coll},
  journal={The American journal of pathology},
  year={1996},
  volume={149 6},
  pages={
          1941-52
        }
}
Neuroendocrine (NE) lung tumors comprise four classes of progressive aggressiveness for which proliferation and apoptosis rates could both contribute to their distinctive behavior. As p53 mutations may favor escape from apoptosis through changes in Bcl2-Bax expression balance, which are survival and apoptotic genes, respectively, we studied 121 NE lung tumors (16 typical carcinoids (TC), 5 atypical carcinoids (AC), 29 large-cell NE carcinomas (LCNECs), and 71 small-cell lung carcinomas (SCLCs… CONTINUE READING

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