Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction.

@article{Weant2008ApoptosisRB,
  title={Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction.},
  author={Ashley E Weant and Ryan D. Michalek and Islam U. Khan and Beth C. Holbrook and Mark C. Willingham and Jason M. Grayson},
  journal={Immunity},
  year={2008},
  volume={28 2},
  pages={218-30}
}
Throughout most of adult life, lymphocyte number remains constant because of a balance of proliferation and apoptosis. Mutation of Bim, a proapoptotic protein in the intrinsic death pathway, or Fas, a tumor necrosis factor receptor (TNFR) superfamily member of the extrinsic pathway, results in late-onset autoimmunity and increased antigen-specific CD8(+) T cell responses during viral infection. However, virus-specific immune responses eventually return to amounts comparable to those for… CONTINUE READING