Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant.

@article{Print1998ApoptosisRB,
  title={Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant.},
  author={Cristin G. Print and Kate L Loveland and Lauren Gibson and Tracy Meehan and Andreas Stylianou and Nigel G. Wreford and David Morritz de Kretser and Donald Metcalf and Frank Koentgen and Jerry M. Adams and Suzanne Cory},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 21},
  pages={12424-31}
}
Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which is widely expressed. To explore its physiological role, we have inactivated the bcl-w gene in the mouse by homologous recombination. Mice that lack Bcl-w were viable, healthy, and normal in appearance. Most tissues exhibited typical histology, and hematopoiesis was unaffected, presumably due to… CONTINUE READING

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