Apoptosis regulation in tetraploid cancer cells.

  title={Apoptosis regulation in tetraploid cancer cells.},
  author={Maria Castedo and Arnaud Coquelle and Sonia Vivet and Ilio Vitale and Audrey Kauffmann and Philippe Dessen and Marie O. Pequignot and Noelia Casares and Alexandre Valent and Shahul Mouhamad and Elise Schmitt and Nazanine Modjtahedi and William Vainchenker and Laurence Zitvogel and Vladimir Lazar and Carmen Garrido and Guido Kroemer},
  journal={The EMBO journal},
  volume={25 11},
Tetraploidy can result in cancer-associated aneuploidy. As shown here, freshly generated tetraploid cells arising due to mitotic slippage or failed cytokinesis are prone to undergo Bax-dependent mitochondrial membrane permeabilization and subsequent apoptosis. Knockout of Bax or overexpression of Bcl-2 facilitated the survival of tetraploid cells at least as efficiently as the p53 or p21 knockout. When tetraploid cells were derived from diploid p53 and Bax-proficient precursors, such cells… CONTINUE READING
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