Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

@article{Li2007ApoptosisRB,
  title={Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.},
  author={Chi Li and Xiaoli Wang and Horia Vais and Craig B Thompson and J. Kevin Foskett and Carl White},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 30},
  pages={12565-70}
}
Members of the Bcl-2 family of proteins regulate apoptosis, with some of their physiological effects mediated by their modulation of endoplasmic reticulum (ER) Ca(2+) homeostasis. Antiapoptotic Bcl-x(L) binds to the inositol trisphosphate receptor (InsP(3)R) Ca(2+) release channel to enhance Ca(2+)- and InsP(3)-dependent regulation of channel gating… CONTINUE READING