Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.

@article{Eckenrode2010ApoptosisPB,
  title={Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.},
  author={Emily F. Eckenrode and Jun Yang and Gopal V. Velmurugan and J. Kevin Foskett and Carl White},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 18},
  pages={13678-84}
}
Members of the Bcl-2 protein family play a central role in the regulation of apoptosis. An interaction between anti-apoptotic Bcl-x(L) and the endoplasmic reticulum (ER)-localized inositol trisphosphate receptor Ca(2+) release channel (InsP(3)R) enables Bcl-x(L) to be fully efficacious as an anti-apoptotic mediator (White, C., Li, C., Yang, J., Petrenko, N. B., Madesh, M., Thompson, C. B., and Foskett, J. K. (2005) Nat. Cell Biol. 7, 1021-1028). Physiologically, Bcl-x(L) binds to the InsP(3)R… CONTINUE READING

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Mentioned Connections BETA
ApoptosisProcess involves geneBCL2 gene
Stable expression of Bcl-2 or Mcl-1 lowered ER Ca(2 + ) content and enhanced the rate of InsP(3)-mediated Ca(2 + ) release in response to submaximal InsP(3 ) stimulation in permeabilized wild - type DT40 cells but not in cells lacking InsP(3)R. In addition , expression of either Bcl-2 or Mcl-1 enhanced spontaneous InsP(3)R - dependent Ca(2 + ) oscillations and spiking in intact cells in the absence of agonist stimulation . Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide
Stable expression of Bcl-2 or Mcl-1 lowered ER Ca(2 + ) content and enhanced the rate of InsP(3)-mediated Ca(2 + ) release in response to submaximal InsP(3 ) stimulation in permeabilized wild - type DT40 cells but not in cells lacking InsP(3)R. In addition , expression of either Bcl-2 or Mcl-1 enhanced spontaneous InsP(3)R - dependent Ca(2 + ) oscillations and spiking in intact cells in the absence of agonist stimulation . Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide
ApoptosisProcess involves geneMCL1 gene
Stable expression of Bcl-2 or Mcl-1 lowered ER Ca(2 + ) content and enhanced the rate of InsP(3)-mediated Ca(2 + ) release in response to submaximal InsP(3 ) stimulation in permeabilized wild - type DT40 cells but not in cells lacking InsP(3)R. In addition , expression of either Bcl-2 or Mcl-1 enhanced spontaneous InsP(3)R - dependent Ca(2 + ) oscillations and spiking in intact cells in the absence of agonist stimulation . Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide
Stable expression of Bcl-2 or Mcl-1 lowered ER Ca(2 + ) content and enhanced the rate of InsP(3)-mediated Ca(2 + ) release in response to submaximal InsP(3 ) stimulation in permeabilized wild - type DT40 cells but not in cells lacking InsP(3)R. In addition , expression of either Bcl-2 or Mcl-1 enhanced spontaneous InsP(3)R - dependent Ca(2 + ) oscillations and spiking in intact cells in the absence of agonist stimulation . Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide
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