Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth.

@article{Sakao2006ApoptosisOP,
  title={Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth.},
  author={Seiichiro Sakao and Laimute Taraseviciene-Stewart and Kathy Wood and Carlyne D Cool and Norbert Felix Voelkel},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 3},
  pages={
          L362-8
        }
}
We have previously hypothesized that the development of severe angioproliferative pulmonary hypertension is associated with not only initial endothelial cell (EC) apoptosis followed by the emergence of apoptosis-resistant proliferating EC but also with proliferation of vascular smooth muscle cells (VSMC). We have demonstrated that EC death results in the selection of an apoptosis-resistant, proliferating, and phenotypically altered EC phenotype. We postulate here that the initial apoptosis of… CONTINUE READING

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