Apoptosis of photoreceptor cells in ornithine-induced retinopathy

  title={Apoptosis of photoreceptor cells in ornithine-induced retinopathy},
  author={Hiroshi Maeda and Nahoko Ogata and Xianjin Yi and Masamitsu Takeuchi and Hiroshi Ohkuma and Masanobu Uyama},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
• Background: The intravitreal injection of ornithine produces selective damage to the retinal pigment epithelium (RPE) and results in a loss of RPE, choriocapillaris and photoreceptor cells. To elucidate the mechanism of secondary retinal atrophy, we investigated the presence of apoptotic cells in a rat model of ornithine-induced retinopathy. • Methods: At 6 and 12 h and 1, 2, 4, 7, 14 and 28 days after an intravitreal injection of L-ornithine hydrochloride in rat eyes, we removed the eyes and… CONTINUE READING
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