Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination.

@article{Caprariello2012ApoptosisOO,
  title={Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination.},
  author={Andrew V Caprariello and Saisho Mangla and Robert H. Miller and Stephen M. Selkirk},
  journal={Annals of neurology},
  year={2012},
  volume={72 3},
  pages={395-405}
}
OBJECTIVE Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that presents with variable pathologies that may reflect different disease-causing mechanisms. Existing animal models of MS induce pathology using either local injection of gliotoxins or stimulation of the immune system with myelin-related peptides. In none of these models is the primary cellular target well characterized, and although demyelination is a hallmark pathological feature in MS, it is unclear… CONTINUE READING