Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis.

@article{Nau1999ApoptosisON,
  title={Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis.},
  author={Roland Nau and Adriana Soto and Wolfgang Br{\"u}ck},
  journal={Journal of neuropathology and experimental neurology},
  year={1999},
  volume={58 3},
  pages={265-74}
}
Apoptosis of granular cells in the dentate gyrus frequently occurs in animal models of bacterial meningitis. In 37 autopsy cases of bacterial meningitis we evaluated, by light microscopy and in-situ tailing, whether this pattern of neuronal damage is of relevance in humans. Neuronal apoptoses in the dentate gyrus (density 1 to 19/mm2) were observed in 26 cases of bacterial meningitis and in none of 10 aged-matched control cases dying from non-neurological diseases. The density of apoptotic… CONTINUE READING

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