Apoptosis of liver-derived cells induced by parvovirus B19 nonstructural protein.

@article{Poole2006ApoptosisOL,
  title={Apoptosis of liver-derived cells induced by parvovirus B19 nonstructural protein.},
  author={Brian D. Poole and Jing Zhou and Amy L Grote and Adam S Schiffenbauer and Stanley J. Naides},
  journal={Journal of virology},
  year={2006},
  volume={80 8},
  pages={4114-21}
}
Parvovirus B19 has been implicated in some cases of acute fulminant non-A, non-B, non-C, non-G liver failure. Our laboratory previously demonstrated that B19 infection of hepatocytes induces apoptosis and that the B19 viral nonstructural protein, NS1, may play a critical role. To study the involvement of NS1 in apoptosis of liver cells, we generated a fusion protein of NS1 with enhanced green fluorescent protein (eGFP) in a system allowing for inducible gene expression. Transfection of the… CONTINUE READING