Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.

@article{Ramanadham2004ApoptosisOI,
  title={Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta.},
  author={Sasanka Ramanadham and F. -F. Hsu and Sheng Zhang and Chun Ji Jin and Alan E. Bohrer and Haowei Song and Shunzhong Bao and Zhongmin Ma and John Turk},
  journal={Biochemistry},
  year={2004},
  volume={43 4},
  pages={918-30}
}
The death of insulin-secreting beta-cells that causes type I diabetes mellitus (DM) occurs in part by apoptosis, and apoptosis also contributes to progressive beta-cell dysfunction in type II DM. Recent reports indicate that ER stress-induced apoptosis contributes to beta-cell loss in diabetes. Agents that deplete ER calcium levels induce beta-cell apoptosis by a process that is independent of increases in [Ca(2+)](i). Here we report that the SERCA inhibitor thapsigargin induces apoptosis in… CONTINUE READING

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