Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury.

@article{Scarabelli2001ApoptosisOE,
  title={Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury.},
  author={Tiziano Maria Scarabelli and Anastasis Stephanou and Nick Rayment and Evasio Pasini and Laura Comini and Salvatore Curello and Roberto Ferrari and Richard J Knight and D. S. Latchman},
  journal={Circulation},
  year={2001},
  volume={104 3},
  pages={253-6}
}
BACKGROUND Apoptosis contributes to cell loss after ischemia/reperfusion injury in the heart. This study describes the time course and level of apoptosis in different cell types in the intact heart during ischemia/reperfusion injury. METHODS AND RESULTS Isolated Langendorff-perfused rat hearts were subjected to perfusion alone (control) or to 35 minutes of regional ischemia, either alone or followed by 5, 60, or 120 minutes of reperfusion. Sections were stained by terminal deoxynucleotidyl… CONTINUE READING

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