Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.

@article{Chen2008ApoptosisOC,
  title={Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.},
  author={Sung-Ho Chen and Jen-kun Lin and Shing Hwa Liu and Yu-Chih Liang and Shoei-Yn Lin-Shiau},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={102 1},
  pages={138-49}
}
Astrocytes play a critical neurotrophic and neuroprotective role in the brain, and improper function of these cells may contribute to the onset of neurodegenerative diseases. Because astrocytes are known to be enriched with Cu chaperone proteins, it is important to understand the factors that may lead to cytotoxic effects of Cu on astrocytes. In this report, we demonstrated a dramatic potentiating effect of neocuproine (NCP), a membrane permeable metal chelator, on Cu, but not Fe or Pb, in… CONTINUE READING
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