Apoptosis of crypt epithelial cells in ulcerative colitis.

  title={Apoptosis of crypt epithelial cells in ulcerative colitis.},
  author={Masaya Iwamoto and Takehiko Koji and Kazuya Makiyama and Nobuyuki Kobayashi and Paul K. Nakane},
  journal={The Journal of pathology},
  volume={180 2},
In the colon of ulcerative colitis (UC) patients, apoptotic bodies have been recognized in routine histopathological preparations. To investigate the extent of the apoptosis, colonic biopsies were examined from involved and uninvolved areas of untreated active UC and from normal areas in patients with colonic polyps, utilizing various markers of apoptosis. The markers included DNA breaks detected by TUNEL, Fas (CD95/APO-1) and Fas ligand (Fas-L) localized by immunohistochemistry, electron… CONTINUE READING

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