Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase.

@article{Szabolcs1996ApoptosisOC,
  title={Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase.},
  author={Matthias J. Szabolcs and Robert E. Michler and Xiang-Qun Yang and W Aji and D F Roy and Eleni S Athan and Robert R. Sciacca and Oktavijan P. Minanov and Paul J. Cannon},
  journal={Circulation},
  year={1996},
  volume={94 7},
  pages={1665-73}
}
BACKGROUND Apoptosis is a distinct form of programmed cell death characterized by activation of endonucleases that cleave nuclear DNA, condensation and fragmentation of nuclear chromatin, blebbing of intact membranes, and cell shrinkage and fragmentation. The mechanisms responsible are unclear, but nitric oxide (NO) generated by inducible NO synthase (iNOS… CONTINUE READING