Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.

@article{Youn1999ApoptosisOT,
  title={Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.},
  author={Hong Duk Youn and Li Sun and Ron Prywes and Jun O Liu},
  journal={Science},
  year={1999},
  volume={286 5440},
  pages={790-3}
}
T cell receptor (TCR)-induced apoptosis of thymocytes is mediated by calcium-dependent expression of the steroid receptors Nur77 and Nor1. Nur77 expression is controlled by the transcription factor myocyte enhancer factor 2 (MEF2), but how MEF2 is activated by calcium signaling is still obscure. Cabin1, a calcineurin inhibitor, was found to regulate MEF2. MEF2 was normally sequestered by Cabin1 in a transcriptionally inactive state. TCR engagement led to an increase in intracellular calcium… CONTINUE READING
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