Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells

@article{Kobayashi2003ApoptosisOT,
  title={Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells},
  author={Sawako Kobayashi and Shuichi Seki and Norifumi Kawada and Hiroyasu Morikawa and Kazuki Nakatani and Naoki Uyama and Kazuo Ikeda and Yuji Nakajima and Tetsuo Arakawa and Kenji Kaneda},
  journal={Cell and Tissue Research},
  year={2003},
  volume={311},
  pages={353-364}
}
Apoptosis of T cells contributes to the immune homeostasis in inflamed organs. A prominent T-cell infiltration is usually seen in human chronic active hepatitis, being associated with liver fibrosis. In order to demonstrate T-cell apoptosis in the hepatic fibrotic tissue, we induced T-cell infiltration in the fibrotic liver of the rat by injecting concanavalin A (Con A), a T-cell mitogen. Lymphocytes increased in number with a peak at 1 day, preferentially distributing in the fibrotic tissue… CONTINUE READING
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