• Biology, Medicine
  • Published in Cancer research 1997

Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins.

@article{Soldatenkov1997ApoptosisOE,
  title={Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins.},
  author={Viatcheslav A. Soldatenkov and Anatoly Dritschilo},
  journal={Cancer research},
  year={1997},
  volume={57 18},
  pages={
          3881-5
        }
}
Induction of apoptosis in Ewing's sarcoma cells by ionizing radiation is accompanied by accumulation of ubiquitinated proteins preferentially in the form of conjugates with M(r) greater than 75,000. Furthermore, enhanced antiubiquitin immunofluorescence was detected only in cells that underwent radiation-induced apoptosis, suggesting that the observed alterations in protein ubiquitination are specific to the apoptotic process. To determine the role of the proteasome in apoptosis-associated… CONTINUE READING

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