Apoptosis modulators in the therapy of neurodegenerative diseases.

  title={Apoptosis modulators in the therapy of neurodegenerative diseases.},
  author={Hans Peter Deigner and Uwe Haberkorn and Ralf Kinscherf},
  journal={Expert opinion on investigational drugs},
  volume={9 4},
Apoptosis is a prerequisite to model the developing nervous system. However, an increased rate of cell death in the adult nervous system underlies neurodegenerative disease and is a hallmark of multiple sclerosis (MS) Alzheimer's- (AD), Parkinson- (PD), or Huntington's disease (HD). Cell surface receptors (e.g., CD95/APO-1/Fas; TNF receptor) and their ligands (CD95-L; TNF) as well as evolutionarily conserved mechanisms involving proteases, mitochondrial factors (e.g. , Bcl-2-related proteins… CONTINUE READING


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