Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes.

@article{Rohrbach2005ApoptosismodulatingIO,
  title={Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes.},
  author={Susanne Rohrbach and Ursula Muller-Werdan and Karl Werdan and Susanne Vinkel Koch and Norbert F Gellerich and J{\"u}rgen Holtz},
  journal={Journal of molecular and cellular cardiology},
  year={2005},
  volume={38 3},
  pages={485-93}
}
During chemotherapy with anthracyclines, attenuated neuregulin signaling by the erbB2 receptor inactivating antibody Trastuzumab enhances the heart failure risk. We compared the effects of attenuated neuregulin/erbB signaling and of daunorubicin on splicing of the Bcl-x gene and on mitochondrial activation of apoptosis in cardiomyocytes. Attenuating erbB signals in cultured neonatal rat cardiomyocytes by the erbB2 antagonist tyrphostin AG825, by the erbB1/4 antagonist AG1478 or by antisense… CONTINUE READING

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