Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

@article{Desmoulire1995ApoptosisMT,
  title={Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.},
  author={Alexis Desmouli{\`e}re and Mireille Redard and Ian Darby and Giulio Gabbiani},
  journal={The American journal of pathology},
  year={1995},
  volume={146 1},
  pages={56-66}
}
Granulation tissue formation and contraction is an important step of second intention wound healing. Granulation tissue develops from the connective tissue surrounding the damaged or missing area and its cellular components are mainly small vessel and inflammatory cells as well as fibroblasts and myofibroblasts. As the wound closes and evolves into a scar, there is an important decrease in cellularity; in particular myofibroblasts disappear. The question arises as to which process is… CONTINUE READING
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