Apoptosis mediated by lentiviral TRAIL transfer involves transduction-dependent and -independent effects

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, which selectively induces apoptosis in many transformed cells without apparent toxic side effects in normal tissue. We recently described the construction and characterization of a lentiviral vector for expression of TRAIL. In this report, we evaluate its… (More)
DOI: 10.1038/sj.cgt.7701016

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