Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B

@inproceedings{Shadab2017ApoptosislikeCD,
  title={Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B},
  author={Md. Shadab and Baijayanti Jha and Mohammad Asad and Makaraju Deepthi and Mohd. Kamran and Nahid Abdelraheem Ali},
  booktitle={PloS one},
  year={2017}
}
OBJECTIVE The present study aimed to elucidate the cell death mechanism in Leishmania donovani upon treatment with KalsomeTM10, a new liposomal amphotericin B. METHODOLOGY/PRINCIPAL FINDINGS We studied morphological alterations in promastigotes through phase contrast and scanning electron microscopy. Phosphatidylserine (PS) exposure, loss of mitochondrial membrane potential and disruption of mitochondrial integrity was determined by flow cytometry using annexinV-FITC, JC-1 and mitotraker… CONTINUE READING
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