- M Sawicka, G L Stritesky, +4 authors K A Hogquist
- Front. Immunol
163 The thymus as the central organ of the immune system is responsible for the maturation of T cells. It is assumed that the formation of the T cell receptor (TCR) is accompanied by the destruction of over 95% of CD4+CD8+ cells. This hypothesis is based on the results of studies obtained in 1960–1970 in vitro, which were extrapolated to the processes in vivo with out experimental confirmation [1, 2]. The mathemat ical models of the processes developed to date, which are based on the existing hypothesis, predict the death of 75% of thymocytes in the course of selection [3, 4]. Solving the problem on the level of apoptosis in maturing T cells is essential for the validation of the model of their intrathymic maturation, including pos itive and negative selection as a prerequisite.