Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

  title={Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.},
  author={Deryk Loo and Agata Copani and Christian J. Pike and Edward R. Whittemore and Andrea J. Walencewicz and Carl Cotman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 17},
  • D. Loo, A. Copani, C. Cotman
  • Published 1 September 1993
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
The molecular mechanism responsible for the neurodegeneration in Alzheimer disease is not known; however, accumulating evidence suggests that beta-amyloid peptide (A beta P) contributes to this degeneration. We now report that synthetic A beta Ps trigger the degeneration of cultured neurons through activation of an apoptotic pathway. Neurons treated with A beta Ps exhibit morphological and biochemical characteristics of apoptosis, including membrane blebbing, compaction of nuclear chromatin… 

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