Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice.

@article{Darby1997ApoptosisII,
  title={Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice.},
  author={Ian Andrew Darby and Teresa Bisucci and Tim D. Hewitson and D G Maclellan},
  journal={The international journal of biochemistry & cell biology},
  year={1997},
  volume={29 1},
  pages={191-200}
}
Impaired wound healing is a common complication of diabetes mellitus. The underlying pathophysiology of diabetes-impaired healing is poorly understood. In the present study we have compared cell proliferation rates, apoptosis (programmed cell death), the myofibroblast marker alpha-smooth muscle actin and procollagen I mRNA expression, between diabetic and control mice. Full-thickness skin wounds were made in non-obese diabetic (NOD) mice and C57B6 controls. NOD mice showed a marked retardation… CONTINUE READING
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