Apoptosis is associated with increased cell surface tissue factor procoagulant activity.

@article{Greeno1996ApoptosisIA,
  title={Apoptosis is associated with increased cell surface tissue factor procoagulant activity.},
  author={Edward W. Greeno and Ronald R. Bach and Charles F. Moldow},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1996},
  volume={75 2},
  pages={
          281-9
        }
}
Tissue factor (TF), the physiologic initiator of coagulation, is present on the surface of cells but is not fully active unless the cell is lysed. This phenomenon, termed TF encryption, may be regulated by changes in membrane structure. Because apoptosis is associated with cell membrane alterations and conditions associated with apoptosis have also been associated with TF de-encryption, we hypothesized that apoptosis would result in enhanced TF procoagulant activity. Cultured human fibroblasts… CONTINUE READING

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