Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

@article{Chen1997ApoptosisIA,
  title={Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding},
  author={Weidong Chen and Gregory Alan Otterson and Stan Lipkowitz and Samir N. Khleif and Amy B. Coxon and Frederic J. Kaye},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={1243-1248}
}
Dephosphorylation of the RB protein has been reported to be associated with apoptosis. In contrast, we show that treatment of HL60 cells with etoposide or cytosine arabinoside or treatment of breast epithelial cells with α-FAS is associated with the cleavage of a 5 kDa fragment from the C-terminus of RB, resulting in a truncated product that we have designated as p100cl. This cleavage event coincides with the activation of cysteine proteases at the onset of apoptosis, is blocked by the addition… CONTINUE READING

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