Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis.

  title={Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis.},
  author={Lars P Bechmann and Robert K. Gieseler and Jan-Peter Sowa and Alisan Kahraman and Jochen Erhard and Inga Wedemeyer and Barbara Emons and Christoph Jochum and Thorsten Feldkamp and Guido G H Gerken and Ali Canbay},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  volume={30 6},
BACKGROUND & AIMS Hepatocyte apoptosis is a key event in non-alcoholic steatohepatitis (NASH). We studied the effect of obesity on free fatty acid (FFA) levels, fatty acid transport proteins (FATPs) and on extrinsic and intrinsic activation of apoptosis in the liver. METHODS Liver biopsies were harvested from 52 morbidly obese patients [body mass index (BMI): 53.82+/-1.41; age: 45+/-10.50; 15 males/37 females] undergoing bariatric surgery, and were scored for NASH, evaluated for fibrosis, and… CONTINUE READING


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