Apoptosis initiated by dependence receptors: a new paradigm for cell death?

Abstract

A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand-dependent neuronal growth and differentiation or axon guidance. Acting as "dependence receptors", they may also regulate neuronal cell survival by inducing apoptosis in the absence of cognate ligand. Receptor-initiated apoptosis requires proteolytic (caspase… (More)

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Cite this paper

@article{Porter2004ApoptosisIB, title={Apoptosis initiated by dependence receptors: a new paradigm for cell death?}, author={Alan Porter and Saravanakumar Dhakshinamoorthy}, journal={BioEssays : news and reviews in molecular, cellular and developmental biology}, year={2004}, volume={26 6}, pages={656-64} }