Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.

@article{Iwamura2012ApoptosisIO,
  title={Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes.},
  author={Yoshihiro Iwamura and Mayumi Mori and Katsuhiko Nakashima and Toshiyuki Mikami and Katsuhisa Murayama and Satoko Arai and Toru Miyazaki},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={422 3},
  pages={476-81}
}
Under fasting conditions, triacylglycerol in adipose tissue undergoes lipolysis to supply fatty acids as energy substrates. Such lipolysis is regulated by hormones, which activate lipases via stimulation of specific signalling cascades. We previously showed that macrophage-derived soluble protein, AIM induces obesity-associated lipolysis, triggering chronic inflammation in fat tissue which causes insulin resistance. However, the mechanism of how AIM mediates lipolysis remains unknown. Here we… CONTINUE READING

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