Apoptosis induction in colon cancer cell lines and alteration of aberrant crypt foci in rat colon by purple rice (Oryza sativa L. var. glutinosa) extracts.

@article{Wongjaikam2014ApoptosisII,
  title={Apoptosis induction in colon cancer cell lines and alteration of aberrant crypt foci in rat colon by purple rice (Oryza sativa L. var. glutinosa) extracts.},
  author={Suwakon Wongjaikam and Ratasak Summart and Teera Chewonarin},
  journal={Nutrition and cancer},
  year={2014},
  volume={66 4},
  pages={
          690-9
        }
}
Crude ethanol extracts (CEE) of purple rice was fractionated to obtain hexane soluble (HSF) and ethyl acetate soluble fractions (EASF). Total antioxidant capacity was higher in CEE than the HSF and EASF. However, HSF exhibited strong antiproliferation and apoptosis induction against colon cancer cell lines, both p53 wild-type (RKO) and mutant (SW620) strains. Then, the CEE was used to determine the effects on the progression of aberrant crypt foci (ACF), a preneoplastic lesion seen in colon… CONTINUE READING
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