Apoptosis induction by epigallocatechin gallate involves its binding to Fas.

@article{Hayakawa2001ApoptosisIB,
  title={Apoptosis induction by epigallocatechin gallate involves its binding to Fas.},
  author={S. Hayakawa and K. Saeki and M. Sazuka and Y. Suzuki and Y. Shoji and T. Ohta and K. Kaji and A. Yuo and M. Isemura},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={285 5},
  pages={
          1102-6
        }
}
Epigallocatechin gallate (EGCG) is known to induce apoptosis in various types of tumor cells, but the precise mechanism by which EGCG induces apoptosis remains to be elucidated. The Fas-Fas ligand system is one of the major pathways operating in the apoptotic cascade. The aim of this study was to examine the possibility that EGCG-binding to Fas triggers the Fas-mediated apoptosis. The EGCG treatment of human monocytic leukemia U937 cells resulted in elevation of caspase 8 activity and… Expand
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