Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92

@article{Matsubara2007ApoptosisIB,
  title={Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92},
  author={Hisahiro Matsubara and Tomoharu Takeuchi and Eri Nishikawa and Kiyoshi Yanagisawa and Yoji Hayashita and Hiromichi Ebi and Hideto Yamada and Masaya Suzuki and Masato Nagino and Yuji Nimura and Hirotaka Osada and Takashi Takahashi},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6099-6105}
}
Amplification and overexpression of the miR-17-92 microRNAs (miRNA) cluster at 13q31.3 has recently reported, with pointers to functional involvement in the development of B-cell lymphomas and lung cancers. In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of ‘OncomiR addiction’ to expression of these miRNAs in a subset of lung… CONTINUE READING
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