Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2.

@article{Wajapeyee2006ApoptosisIB,
  title={Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2.},
  author={Narendra Wajapeyee and Ramona Britto and Halasahalli M Ravishankar and Kumaravel Somasundaram},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 24},
  pages={16207-19}
}
Activator protein 2alpha (AP-2alpha) induces cytotoxicity by inducing cell cycle arrest and apoptosis. In this study we investigated the mechanism of apoptosis induction by AP-2alpha. We found that AP-2alpha induced apoptosis efficiently in cells treated with benzyloxycar-bonyl-IETD-fluoromethyl ketone or FADD-silenced cells but failed to do so in benzyloxycarbonyl-LEHD-fluoromethyl ketone-treated or apoptosis protease activation factor-1 (Apaf1)-silenced cells, suggesting the central role of… CONTINUE READING