Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.

@article{Duarte2007ApoptosisIA,
  title={Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.},
  author={No{\'e}lia Duarte and Andr{\'a}s Varga and Georg Cherepnev and Rita Radics and J{\'o}zsef Moln{\'a}r and Maria-Jos{\'e} U. Ferreira},
  journal={Bioorganic & medicinal chemistry},
  year={2007},
  volume={15 1},
  pages={546-54}
}
The macrocyclic lathyrane diterpenes, latilagascenes D-F (1-3) and jolkinol B (4), were isolated from the methanol extract of Euphorbia lagascae, and evaluated for multidrug resistance reversing activity on mouse lymphoma cells. All compounds displayed very strong activity compared with that of the positive control, verapamil. The structure-activity relationship is discussed. The evaluation of compounds 1 and 4, and of latigascenes A-C (5-7), isolated from the same species, as apoptosis… CONTINUE READING
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