Apoptosis induction and histological changes in rat kidney following Cd-doped silica nanoparticle exposure: evidence of persisting effects.

@article{Coccini2013ApoptosisIA,
  title={Apoptosis induction and histological changes in rat kidney following Cd-doped silica nanoparticle exposure: evidence of persisting effects.},
  author={Teresa Coccini and Sergio Barni and Luigi Manzo and Elisa Roda},
  journal={Toxicology mechanisms and methods},
  year={2013},
  volume={23 8},
  pages={566-75}
}
Abstract Histological and immunocytochemical methods were used to examine rat's renal responses to intratracheal (i.t.) instillation of model cadmium-containing silica nanoparticles (Cd-SiNPs) and also exploring whether these potential modifications would be associated with toxicogenomic changes. Renal effects of Cd-SiNPs (1 mg/rat), CdCl2 (400 µg/rat), SiNPs (600 µg/rat) or 0.1 ml saline (control), assessed 7 and 30 d post-i.t., included (i) induction of apoptosis, (ii) cell proliferation and… CONTINUE READING

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