Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients

@article{Burguillos2011ApoptosisinducingFM,
  title={Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients},
  author={Miguel Angel Burguillos and Najat Hajji and Emelie Englund and Alexander Persson and Jose Luis Venero},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={177-188}
}
We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. In contrast, nigral DA neurons exhibited AIF nuclear translocation in response to LPS. A significant decrease of the Bcl-2/Bax ratio in nigral tissue after LPS injection was observed. We next developed an in vitro co-culture system with the microglial BV2 and the DA neuronal… CONTINUE READING

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