Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation.

@article{Madge1999ApoptosisinducingAC,
  title={Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation.},
  author={Lisa A. Madge and M. Rocio Sierra-Honigmann and Jordan S Pober},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 19},
  pages={13643-9}
}
Several chemical compounds not known to interact with tumor necrosis factor (TNF) signal transducing proteins inhibit TNF-mediated activation of vascular endothelial cells (EC). Four structurally diverse agents, arachidonyl trifluoromethylketone, staurosporine, sodium salicylate, and C6-ceramide, were studied. All four agents caused EC apoptosis at… CONTINUE READING