Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells.

@article{Sergeev2007ApoptosisinducingAO,
  title={Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells.},
  author={Igor N. Sergeev and Chitang Ho and Shiming Li and Julie Colby and Slavik Dushenkov},
  journal={Molecular nutrition & food research},
  year={2007},
  volume={51 12},
  pages={1478-84}
}
Sweet orange (Citrus sinensis L.) peel is a rich resource of flavonoids, especially polymethoxyflavones (PMFs). Citrus flavonoids exert a broad spectrum of biological activity, including antiproliferative and proapoptotic effects in cancer cells. We have recently shown that individual PMFs from orange peel induce Ca(2+)-mediated apoptosis in human breast cancer cells and that hydroxylation of PMFs is critical for enhancing their proapoptotic activity. Here, we report that the fraction of orange… CONTINUE READING

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