Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

@article{Gottlieb1996ApoptosisII,
  title={Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.},
  author={Roberta A Gottlieb and Janne Nordberg and Evan Skowronski and Bernard M. Babior},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 2},
  pages={654-8}
}
We have previously shown that in neutrophils deprived of granulocyte colony-stimulating factor, apoptosis is preceded by acidification and that the protection against apoptosis conferred on neutrophils by granulocyte colony-stimulating factor is dependent upon delay of this acidification. To test the hypothesis that acidification could be a general feature of apoptosis, we examined intracellular pH changes in another cell line. Jurkat cells, a T-lymphoblastoid line, were induced to undergo… CONTINUE READING
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