Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E.

@article{SoferLevi1996ApoptosisIB,
  title={Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E.},
  author={Y Sofer-Levi and Dalia Resnitzky},
  journal={Oncogene},
  year={1996},
  volume={13 11},
  pages={2431-7}
}
Deregulation of the pRb/E2F pathway leads to disruption of the normal control of the G1/S transition, and is associated with transformation. However, recent accumulated evidence suggest that under certain circumstances deregulation of the pRb/E2F pathway can also lead to apoptotic cell death. Apoptosis was shown to be induced by expression of DNA tumor virus oncoproteins, knockout of the rb gene, and expression of E2F from heterologous promoter. Since phosphorylation of pRb by G1 cyclin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Similar Papers

Loading similar papers…