Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways

@article{Baldys2006ApoptosisIB,
  title={Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways},
  author={Aleksander Baldys and Priyadarshini Pande and Tariq A Mosleh and Sun-Hee Park and Ann E. Aust},
  journal={Apoptosis},
  year={2006},
  volume={12},
  pages={433-447}
}
Exposure of human lung epithelial (A549) cells to asbestos fibers causes apoptosis, which is largely attributed to release of iron and generation of reactive oxygen species (ROS) within the cells. To mimic the highly oxidative environment generated by asbestos exposure in the absence of the actual fibers, we used two chemicals; buthione sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis and ferric ammonium citrate (FAC), a source of iron. Here, we report that exposure of A549 cells… CONTINUE READING
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