Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53

@article{Guo2011ApoptosisIB,
  title={Apoptosis induced by an antagonist peptide against HPV16 E7 in vitro and in vivo via restoration of p53},
  author={Caiping Guo and Kewei Liu and Yi cheng Zheng and Haibo Luo and Hongbo Chen and Laiqiang Huang},
  journal={Apoptosis},
  year={2011},
  volume={16},
  pages={606-618}
}
Human papilloma virus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. A novel antagonist peptide against HPV16 E7 was previously selected by phage display screening and the selected peptide was found to have anti-tumor efficacy against HPV16-positive cervical carcinoma through induction of cell cycle arrest. In the current study, to further elucidate the mechanisms of the antagonist peptide, the effects of the peptide on apoptosis are… CONTINUE READING